hCLDN6(Claudin6)/MC-38
CBPG0050
询 价
留 言
产品描述
产品数据库
| I. Background | |||
|
CLDNs 是上皮细胞紧密连接的主要成分。CLDN6 是紧密连接家族（CLDNs）的一 员，是一个四次跨膜蛋白，具有较短的胞质 N 端和 C 端胞质结构域、两个胞外结构域（较 大的 ECL1 和较小的 ECL2）和一个短的胞内环。CLDN6 可参与乳腺癌、胃癌、肝细胞癌 等多种恶性肿瘤的发生开展。CLDN6 具有重要的生物学功能，其异常表达与丙型肝炎感染 有关。
|
|||
| II. Introduction | |||
| Host Cell: | MC-38 | ||
| Expressed gene: | hCLDN6(Claudin6) | ||
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) | ||
| Freeze Medium: | 90% FBS+10% DMSO | ||
| Culture Medium: | DMEM+10%FBS+2 μg/ml Puromycin | ||
| Mycoplasma Testing: | Negative | ||
| Storage: | Liquid nitrogen | ||
| III. Description of Host Cell Line | |||
| Organism: | Mus musculus, mouse | ||
| Tissue: | Colon | ||
| Morphology: | Epitheloid cell | ||
| Growth Properties: | Adherent | ||
| IV. Representative Data | ||
|
Figure 1. Recombinant hCLDN6(Claudin6)/MC38 stably expressing CLDN6. |
||
| V. In VIVO Data | ||
|
Index |
Content |
|
Animal |
C57BL/6J, 6weeks, female |
|
Implanted Position |
Subcutaneous (right lower flank region ) |
|
Injected Cell Numbers |
1×10^6/0.1ml |
|
Matrix gel |
Without matrix gel |
1. Weight Change
Figure 2. hCLDN6(Claudin6)/MC38 Mean Body Weight ± SEM.
2. Tumor Size
Figure 3. hCLDN6(Claudin6)/MC38 Mean Tumor Volume ± SEM .
NOTE：The above data was provided by Cobioer (cell data) and Truway Bio (in vivo data model).
